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Effects of mTOR Inhibitor-Related Proteinuria on Progression of Cardiac Allograft Vasculopathy and Outcomes among Heart Transplant Recipients

from American Journal of Transplantation

Effects of mTOR Inhibitor-Related Proteinuria on Progression of Cardiac Allograft Vasculopathy and Outcomes among Heart Transplant Recipients American Journal of Transplantation We have previously described the use of sirolimus (SRL) as primary immunosuppression following heart transplantation (HT). The advantages of this approach include attenuation of cardiac allograft vasculopathy (CAV), improvement in glomerular filtration rate (GFR) and reduced malignancy. However, in some patients SRL may cause significant proteinuria. We sought to investigate the prognostic value of proteinuria after conversion to SRL. READ MORE

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