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HLA-DQ mismatches stimulate de novo donor specific antibodies in heart transplant recipients

from Human Immunology

HLA-DQ mismatches stimulate de novo donor specific antibodies in heart transplant recipients Human Immunology The development of donor specific antibody is associated with graft rejection and increased mortality in solid organ transplant recipients. The majority of de novo donor specific antibodies (dnDSA) are against HLA-DQ antigens, but it has not been investigated if this is caused by more mismatches in the HLA-DQ locus between the recipient and donor. READ MORE

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