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Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis

from Arthritis & Rheumatology

Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis Arthritis & Rheumatology Inhibition of hedgehog (HH) signaling prevents cartilage degeneration and promotes repair in animal models of osteoarthritis (OA). This study, undertaken in OA models and in human OA articular cartilage, was designed to explore whether kappa opioid receptor (KOR) modulation via the inhibition of HH signaling may have therapeutic potential for achieving disease-modifying activity in OA. READ MORE

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