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Study suggests 86-SNV be incorporated in breast cancer risk predication models

from Cancer Network

Study suggests 86-SNV be incorporated in breast cancer risk predication models Cancer Network Researchers specifically suggested that the 86-SNV score could be incorporated into breast cancer risk prediction models for patients carrying a pathogenic variant in BRCA1, BRCA2, and CHEK2. Stratification of breast cancer risk by an 86-single nucleotide variation (SNV; formerly single-nucleotide polymorphisms) polygenic risk score (PRS) in pathogenic variant carriers of moderate-risk breast cancer genes was associated with risk changes for women at the lower and higher ends of the risk spectrum, according to study results published in JAMA Network Open. READ MORE

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