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Cervical cancer study in Ugandan women finds HPV-specific tumor DNA methylation, gene expression

from Genome Web

Cervical cancer study in Ugandan women finds HPV-specific tumor DNA methylation, gene expression Genome Web An analysis of cervical cancer in Ugandan patients has mapped epigenome and transcriptome landscapes that are specific to the human papillomavirus clade from which that particular cancer arose. In a study published on Monday in Nature Genetics, an international team of researchers wrote that cervical cancer is the most common cancer affecting sub-Saharan African women, and is particularly prevalent among HIV-positive individuals. HPV-16 (clade A9) is common in both squamous cell carcinomas and adenocarcinomas, while HPV-18 (clade A7) is associated with adenocarcinomas and inferior survival. Although cervical cancer prevention strategies include vaccination and screening for HPV, vaccine use remains low in low- and middle-income countries where HIV is prevalent, they said. READ MORE

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