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Addition of U0126 Protecting Heart Grafts From Prolonged Cold Ischemia Reperfusion Injury in Heart Transplantation

from Transplantation

Addition of U0126 Protecting Heart Grafts From Prolonged Cold Ischemia Reperfusion Injury in Heart Transplantation Transplantation Ischemia reperfusion injury (IRI) is the major cause of primary graft dysfunction in organ transplantation. The MEK/ERK signaling pathway plays a crucial role in cell physiological and pathological processes including IRI. This study aims to investigate whether inhibition of ERK signaling with U0126 can prevent prolonged cold IRI in heart transplantation. READ MORE

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