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Nitric oxide and the brain. Part 1: Mechanisms of regulation, transport and effects on the developing brain

from <i>Pediatric Research</i> – Authors include SPR Member Lina Chalak

Nitric oxide and the brain. Part 1: Mechanisms of regulation, transport and effects on the developing brain Pediatric Research – Authors include SPR Member Lina Chalak Apart from its known actions as a pulmonary vasodilator, nitric oxide (NO) is a key signal mediator in the neonatal brain. Despite the extensive use of NO for pulmonary artery hypertension (PAH), its actions in the setting of brain hypoxia and ischemia, which co-exists with PAH in 20–30% of affected infants, are not well established. This review focuses on the mechanisms of actions of NO covering the basic, translational, and clinical evidence of its neuroprotective and neurotoxic properties. In this first part, we present the physiology of transport and delivery of NO to the brain and the regulation of cerebrovascular and systemic circulation by NO, as well the role of NO in the development of the immature brain. READ MORE

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