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Leukocyte-Dependent Effects of Platelet Rich Plasma on Cartilage Loss and Thermal Hyperalgesia

from Osteoarthritis and Cartilage

Leukocyte-Dependent Effects of Platelet Rich Plasma on Cartilage Loss and Thermal Hyperalgesia Osteoarthritis and Cartilage Platelet-rich plasma (PRP) is an emerging therapeutic strategy for treatment of osteoarthritis (OA); however, there is a lack of preclinical and clinical evidence for its efficacy and its mechanism of action is unclear. In the current study, we utilized leukocyte poor-PRP (LP-PRP) and leukocyte rich- PRP (LR-PRP) to mimic clinical point of care formulations and assessed their potential to alter disease progression in a mouse model of post-traumatic OA. READ MORE

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