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In a subset of patients presenting to emergency departments with suspected sepsis, early administration of antibiotics might have done more harm than good, researchers found.
In an analysis of records for more than 58,000 patients, early antibiotic administration was associated with higher mortality among those with 10% predicted mortality and 20% predicted infection, (absolute mortality difference 1%; 95% CI 0.4%-1.9%), reported Ian Barbash, M.D., of the University of Pittsburgh, at the virtual conference of the American Thoracic Society.
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