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Nuclear heme oxidase-1 inhibits endoplasmic reticulum stress-mediated apoptosis after spinal cord injury

from BioMed Research International

Nuclear heme oxidase-1 inhibits endoplasmic reticulum stress-mediated apoptosis after spinal cord injury BioMed Research International The treatment goal for spinal cord injury (SCI) is to repair neurites and suppress cellular apoptosis. This study is to investigate the effects of nuclear heme oxidase-1 (HO-1) on the acute spinal cord injury and the related mechanisms. The rat model of the SCI was established. On day 7, before model establishment, the adenovirus vector carrying nuclear HO-1 (Ad-GFP-HO-1CΔ23) was injected into the animals into the tenth thoracic spine (T10) segment by the intrathecal injection. READ MORE

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