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The pulmonary pathobiology of patients who died from respiratory failure caused by coronavirus disease 2019 (COVID-19) versus influenza was found to be distinct, according to a study published in the New England Journal of Medicine. "Our finding of enhanced intussusceptive angiogenesis in the lungs from patients with COVID-19 as compared with the lungs from patients with influenza was unexpected," noted the research authors. "New vessel growth can occur by conventional sprouting or intussusceptive (nonsprouting) angiogenesis. The characteristic feature of intussusceptive angiogenesis is the presence of a pillar or post spanning the lumen of the vessel."
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