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Rapamycin and Dexamethasone During Pregnancy Prevents Tuberous Sclerosis Complex Associated Cystic Kidney Disease

from Physician's Weekly

Rapamycin and Dexamethasone During Pregnancy Prevents Tuberous Sclerosis Complex Associated Cystic Kidney Disease Physician's Weekly Chronic kidney disease is the main cause of mortality in patients with tuberous sclerosis complex disease (TSC). The mechanisms underlying TSC cystic kidney disease remain unclear with no available interventions to prevent cyst formation. Using targeted deletion of TSC1 in nephron progenitor cells, we showed that cysts in TSC1 null embryonic kidneys originate from injured proximal tubular cells with high mTOR complex 1 activity. READ MORE

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