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Progressive vasoconstriction with sequential thermal stimulation indicates vascular dysautonomia in sickle cell disease

from Blood

Progressive vasoconstriction with sequential thermal stimulation indicates vascular dysautonomia in sickle cell disease Blood Sickle cell disease (SCD) subjects exhibit subjective hypersensitivity to cold and heat perception in experimental settings, and triggers such as cold exposure are known to precipitate vaso-occlusive crisis by still unclear mechanisms. Decreased microvascular blood flow (MBF) increases the likelihood of vaso-occlusion by increasing entrapment of sickled red blood cells in the microvasculature. As SCD subjects have dysautonomia, researchers anticipated that thermal exposure would induce autonomic hypersensitivity of their microvasculature with an increased propensity towards vasoconstriction. READ MORE

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