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Successful treatment of relapsed pediatric acute myeloid leukemia presenting as central nervous system myeloid sarcoma

from Journal of Pediatric Hematology/Oncology

Successful treatment of relapsed pediatric acute myeloid leukemia presenting as central nervous system myeloid sarcoma Journal of Pediatric Hematology/Oncology Relapsed acute myeloid leukemia presenting as an isolated central nervous system myeloid sarcoma (CNS MS) is very rare and generally entails poor outcomes. CNS MS treatment is not well defined and can include systemic chemotherapy, intrathecal chemotherapy, radiation therapy, or hematopoietic stem cell transplant. Thiotepa, vinorelbine, topotecan and clofarabine (TVTC) has been successful for reinduction therapy in relapsed/refractory leukemia to induce remission before hematopoietic stem cell transplant. There is no published evidence of TVTC being utilized for CNS MS. READ MORE

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