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Tumor mutational burden and driver mutations: Characterizing the genomic landscape of pediatric brain tumors

from Pediatric Blood & Cancer

Tumor mutational burden and driver mutations: Characterizing the genomic landscape of pediatric brain tumors Pediatric Blood & Cancer Tumor mutational burden (TMB) and driver mutations are potential biomarkers to guide targeted therapy selection. Malignant gliomas with high TMB in children may preferentially benefit from treatment with immune checkpoint inhibitors (ICPIs). Higher TMB may relate to lower incidence of driver mutations, but this relationship has not been studied in pediatric brain tumors. READ MORE

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