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Administration of vasopressor agents like norepinephrine can be useful in treating hypotensive septic shock patients. But with any treatment, there are risks associated which must be weighed into individual clinical cases. Sepsis is characterized by a dysfunctional immune response to infection — norepinephrine can contribute to this immune dysregulation. In order to explore the immune response impact of norepinephrine, a team from the Radboud Centre for Infectious Diseases in Nijmegen, the Netherlands, looked at immunomodulation associated with the agent alongside that caused by the alternate vasopressor vasopressin.
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