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Secondary tumor risk in pediatric cancer survivors linked to germline variants, treatment type

from Precision Oncology News

Secondary tumor risk in pediatric cancer survivors linked to germline variants, treatment type Precision Oncology News Secondary cancer risk appears to jump in pediatric cancer patients carrying risky germline variants in DNA repair genes who are exposed to DNA-damaging treatments such as chemotherapy or radiotherapy as part of their original treatment, new research suggests. For a study published in the Journal of Clinical Oncology, a team led by investigators at St. Jude Children's Research Hospital did whole-genome sequencing on blood samples from 4,402 pediatric cancer survivors in the St. Jude Lifetime Cohort, including 495 individuals who went on to develop more than 1,200 secondary neoplasms, focusing on pathogenic germline alterations affecting more than 100 genes from half a dozen DNA repair pathways. READ MORE

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