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Association of aberrant imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL

from Blood

Association of aberrant imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL Blood Karyotype is an important prognostic factor in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), but the underlying pharmacogenomics remains unknown. Asparaginase is an integral component in current chemotherapy for childhood BCP-ALL. Asparaginase therapy depletes serum asparagine. Normal hematopoietic cells can produce asparagine by asparagine synthetase (ASNS) activity, while ALL cells are unable to synthesize adequate amounts of asparagine. READ MORE

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