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Measuring hydroxyurea adherence by pharmacy and laboratory data compared with video observation in children with sickle cell disease

from Pediatric Blood & Cancer

Measuring hydroxyurea adherence by pharmacy and laboratory data compared with video observation in children with sickle cell disease Pediatric Blood & Cancer Hydroxyurea nonadherence is common among children with sickle cell disease (SCD), but it is unclear if current adherence measures are valid compared with video directly observed therapy (VDOT), a reference method. The objectives were to evaluate if hydroxyurea adherence by pharmacy records, urine assay, mean corpuscular volume (MCV), and/or fetal hemoglobin (HbF) correlated with and was sensitive and specific compared with VDOT. READ MORE

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