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CTLA4-Ig Prolongs Graft Survival Specifically in Young but Not Old Mice

from American Journal of Transplantation

CTLA4-Ig Prolongs Graft Survival Specifically in Young but Not Old Mice American Journal of Transplantation Elderly organ transplant recipients have remained underrepresented in clinical trials, despite representing a rapidly growing population. Here, we assessed age‐specific effects of CTLA4‐Ig, a fusion protein blocking costimulatory signaling between APCs and T cells through CD28. READ MORE

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